| http://purl.uniprot.org/citations/34769086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34769086 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34769086 | http://www.w3.org/2000/01/rdf-schema#comment | "A comparison of overlapping proximity captures at the head region of the ribosomal 40S subunit (hr40S) in Saccharomyces cerevisiae from four adjacent perspectives, namely Asc1/RACK1, Rps2/uS5, Rps3/uS3, and Rps20/uS10, corroborates dynamic co-localization of proteins that control activity and fate of both ribosomes and mRNA. Co-locating factors that associate with the hr40S are involved in (i) (de)ubiquitination of ribosomal proteins (Hel2, Bre5-Ubp3), (ii) clamping of inactive ribosomal subunits (Stm1), (iii) mRNA surveillance and vesicular transport (Smy2, Syh1), (iv) degradation of mRNA (endo- and exonucleases Ypl199c and Xrn1, respectively), (v) autophagy (Psp2, Vps30, Ykt6), and (vi) kinase signaling (Ste20). Additionally, they must be harmonized with translation initiation factors (eIF3, cap-binding protein Cdc33, eIF2A) and mRNA-binding/ribosome-charging proteins (Scp160, Sro9). The Rps/uS-BioID perspectives revealed substantial Asc1/RACK1-dependent hr40S configuration indicating a function of the β-propeller in context-specific spatial organization of this microenvironment. Toward resolving context-specific constellations, a Split-TurboID analysis emphasized the ubiquitin-associated factors Def1 and Lsm12 as neighbors of Bre5 at hr40S. These shuttling proteins indicate a common regulatory axis for the fate of polymerizing machineries for the biosynthesis of proteins in the cytoplasm and RNA/DNA in the nucleus."xsd:string |
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| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Valerius O."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Valerius O."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Schmitt K."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Schmitt K."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Kraft A.A."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/author | "Kraft A.A."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/name | "Int. J. Mol. Sci."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/name | "Int. J. Mol. Sci."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/title | "A multi-perspective proximity view on the dynamic head region of the ribosomal 40S subunit."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/title | "A multi-perspective proximity view on the dynamic head region of the ribosomal 40S subunit."xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/34769086 | http://purl.uniprot.org/core/volume | "22"xsd:string |
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