| http://purl.uniprot.org/citations/34769128 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34769128 | http://www.w3.org/2000/01/rdf-schema#comment | "Chronic kidney disease (CKD), secondary to renal fibrogenesis, is a public health burden. The activation of interstitial myofibroblasts and excessive production of extracellular matrix (ECM) proteins are major events leading to end-stage kidney disease. Recently, interleukin-15 (IL-15) has been implicated in fibrosis protection in several organs, with little evidence in the kidney. Since endogenous IL-15 expression decreased in nephrectomized human allografts evolving toward fibrosis and kidneys in the unilateral ureteral obstruction (UUO) model, we explored IL-15's renoprotective role by pharmologically delivering IL-15 coupled or not with its soluble receptor IL-15Rα. Despite the lack of effects on myofibroblast accumulation, both IL-15 treatments prevented tubulointerstitial fibrosis (TIF) in UUO as characterized by reduced collagen and fibronectin deposition. Moreover, IL-15 treatments inhibited collagen and fibronectin secretion by transforming growth factor-β (TGF-β)-treated primary myofibroblast cultures, demonstrating that the antifibrotic effect of IL-15 in UUO acts, in part, through a direct inhibition of ECM synthesis by myofibroblasts. In addition, IL-15 treatments resulted in decreased expression of monocyte chemoattractant protein 1 (MCP-1) and subsequent macrophage infiltration in UUO. Taken together, our study highlights a major role of IL-15 on myofibroblasts and macrophages, two main effector cells in renal fibrosis, demonstrating that IL-15 may represent a new therapeutic option for CKD."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms222111698"xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Candelier J.J."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Giron-Michel J."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Ferlicot S."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Francois H."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Devocelle A."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Lecru L."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/author | "Bessede T."xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/pages | "11698"xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/title | "IL-15 Prevents Renal Fibrosis by Inhibiting Collagen Synthesis: A New Pathway in Chronic Kidney Disease?"xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/34769128 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34769128 |
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