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http://purl.uniprot.org/citations/34774850 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundSeveral past studies have reported the overexpression of Flotillin-1 in a variety of cancer types. Cisplatin is a chemotherapeutic drug commonly used for cancer treatment. The present study investigated the role of Flotillin-1 in the progression of GC and assessed whether it assists in the chemical sensitization of GC cells toward cisplatin.MethodThe expression of Flotillin-1 was detected both in human gastric mucosal cells and GC cells. Next, siRNA and shRNA were used to construct a stable cell line expressing low levels of Flotillin-1. Furthermore, the Cell Counting Kit 8 (CCK-8), flow cytometry, and transwell assays were employed to detect the impact of Flotillin-1 on GC cells. In addition, a nude mouse model of human GC was used to verify the knockdown of Flotillin-1 to increase the sensitivity of GC cells to cisplatin.ResultsFlotillin-1 was overexpressed in GC cells when compared to that in human gastric mucosal cells. The results for in vitro and vivo assays revealed that the knockdown of Flotillin-1 could significantly inhibit the proliferation of GC cells and increased the sensitivity of GC cells to cisplatin via the regulation of the protein kinase B (AKT) and extracellular signal-regulated kinase (ERK) signaling pathway.ConclusionFlotillin-1 might be used as a molecular marker for GC diagnosis and could be explored as a potential new target for the treatment of GC."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ejphar.2021.174631"xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/author | "Ding Y."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/author | "He S."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/author | "Lu Y."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/author | "Wang R."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/author | "Wei J."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/name | "Eur J Pharmacol"xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/pages | "174631"xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/title | "Flotillin-1 promotes progression and dampens chemosensitivity to cisplatin in gastric cancer via ERK and AKT signaling pathways."xsd:string |
http://purl.uniprot.org/citations/34774850 | http://purl.uniprot.org/core/volume | "916"xsd:string |
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