| http://purl.uniprot.org/citations/34780078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34780078 | http://www.w3.org/2000/01/rdf-schema#comment | "Inflammation is of critical importance in successful implantation during pregnancy. However, the establishment of maternal immune tolerance towards semi-allograft foetus is more exigent and is achieved predominantly by human leukocyte antigen-G (HLA-G) isoforms with a special emphasis on soluble HLA-G5 (sHLA-G5). Constant inflammation and lack of resolution by anti-inflammatory milieu, due to aberrant expression of critical immunoregulatory molecules such as sHLA-G5 and dysfunctional T helper cells 1 and 2 (Th1-Th2) cytokine shift, can lead to adverse pregnancy outcomes including recurrent pregnancy loss (RPL). Serum samples of 270 pregnant women (135 healthy parous and 135 with a history of RPL) were evaluated for the concentrations of sHLA-G5, interleukin-4 (IL-4) and tumour necrosis factor-alpha (TNF-α) using sandwich enzyme-linked immunosorbent assay (ELISA) and found elevated levels of sHLA-G5 and IL-4 in controls and higher TNF-α levels and TNF-α:IL-4 ratio in patients (P < .05). Stratified data analysis based on the time of sample collection, that is the first and second trimesters exhibited higher sHLA-G5 and IL-4 in both first and second trimesters in controls than patients, while they displayed lower levels concerning TNF-α and TNF-α:IL-4 ratio (P < .05). However, within patients and controls in the first or second trimesters, there was a significant variation concerning sHLA-G5 alone. Further, the outcome of pregnancies studied in the present investigation revealed a significant elevation in sHLA-G5 levels among women with successful pregnancies compared with women who experienced pregnancy loss, therefore, concluding the potential application of sHLA-G5 isoform as a marker in assisting improved pregnancy outcomes."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.org/dc/terms/identifier | "doi:10.1111/sji.13095"xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/author | "Jahan P."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/author | "Goli M."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/author | "Dirsipam K."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/author | "Madduru D."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/author | "Ramana Devi V."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/name | "Scand J Immunol"xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/pages | "e13095"xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/title | "Association of reduced maternal sHLA-G5 isoform levels and elevated TNF-alpha/IL-4 cytokine ratio with Recurrent Pregnancy Loss: A study on South Indian women."xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/34780078 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34780078 |
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| http://purl.uniprot.org/uniprot/#_A0A0H4M9Y0-mappedCitation-34780078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780078 |
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| http://purl.uniprot.org/uniprot/#_A0A0H4LTY3-mappedCitation-34780078 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780078 |