| http://purl.uniprot.org/citations/34780467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34780467 | http://www.w3.org/2000/01/rdf-schema#comment | "Identifying a common oncogenesis pathway among tumors with different oncogenic mutations is critical for developing anti-cancer strategies. Here, we performed transcriptome analyses on two different models of Drosophila malignant tumors caused by Ras activation with cell polarity defects (RasV12/scrib-/-) or by microRNA bantam overexpression with endocytic defects (bantam/rab5-/-), followed by an RNAi screen for genes commonly essential for tumor growth and malignancy. We identified that Juvenile hormone Inducible-21 (JhI-21), a Drosophila homolog of the L-amino acid transporter 1 (LAT1), is upregulated in these malignant tumors with different oncogenic mutations and knocking down of JhI-21 strongly blocked their growth and invasion. JhI-21 expression was induced by simultaneous activation of c-Jun N-terminal kinase (JNK) and Yorkie (Yki) in these tumors and thereby contributed to tumor growth and progression by activating the mTOR-S6 pathway. Pharmacological inhibition of LAT1 activity in Drosophila larvae significantly suppressed growth of RasV12/scrib-/-tumors. Intriguingly, LAT1 inhibitory drugs did not suppress growth of bantam/rab5-/- tumors and overexpression of bantam rendered RasV12/scrib-/-tumors unresponsive to LAT1 inhibitors. Further analyses with RNA sequencing of bantam-expressing clones followed by an RNAi screen suggested that bantam induces drug resistance against LAT1 inhibitors via downregulation of the TMEM135-like gene CG31157. Our observations unveil an evolutionarily conserved role of LAT1 induction in driving Drosophila tumor malignancy and provide a powerful genetic model for studying cancer progression and drug resistance."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pgen.1009893"xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Nakamura M."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Cong B."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Igaki T."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Ohsawa S."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/author | "Sando Y."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/name | "PLoS Genet"xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/pages | "e1009893"xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/title | "JNK and Yorkie drive tumor malignancy by inducing L-amino acid transporter 1 in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/34780467 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34780467 |
| http://purl.uniprot.org/citations/34780467 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34780467 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-34780467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780467 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-34780467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780467 |
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| http://purl.uniprot.org/uniprot/#_E1JHD6-mappedCitation-34780467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780467 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K6I1-mappedCitation-34780467 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34780467 |