| http://purl.uniprot.org/citations/34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34781202 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic spines are the postsynaptic structure to mediate signal transduction in neural circuitry, whose function and plasticity are regulated by organization of their molecular architecture and by the expression of target genes and proteins. EphB2, a member of the Eph receptor tyrosine kinase family, potentiates dendritic spine maturation through cytoskeleton reorganization and protein trafficking. However, the transcriptional mechanisms underlying prolonged activation of EphB2 signaling during dendritic spine morphogenesis are unknown. Herein, we performed transcriptional profiling by stimulating EphB2 signaling and identified differentially expressed genes implicated in pivotal roles at synapses. Notably, we characterized an F-actin binding protein, Annexin A1, whose expression was induced by EphB2 signaling; the promotor activity of its coding gene Anxa1 is regulated by the activity of CREB (cAMP-response element-binding protein). Knockdown of Annexin A1 led to a significant reduction of mature dendritic spines without an obvious deficit in the complexity of dendrites. Altogether, our findings suggest that EphB2-induced, CREB-dependent Annexin A1 expression plays a key role in regulating dendritic spine morphology."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2021.11.011"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Chen Y."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Liu S."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Ma S."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Sun C."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Yuan L."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Yi W."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Chen Y.'"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/author | "Chen Y.''"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/name | "Biochem Biophys Res Commun"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/pages | "107-115"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/title | "EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis."xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://purl.uniprot.org/core/volume | "584"xsd:string |
| http://purl.uniprot.org/citations/34781202 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34781202 |
| http://purl.uniprot.org/citations/34781202 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34781202 |
| http://purl.uniprot.org/uniprot/#_E2I6F7-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |
| http://purl.uniprot.org/uniprot/#_B7Z7P1-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |
| http://purl.uniprot.org/uniprot/#_B4DQP7-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |
| http://purl.uniprot.org/uniprot/#_B4DSE0-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |
| http://purl.uniprot.org/uniprot/#_B4DL19-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |
| http://purl.uniprot.org/uniprot/#_B7Z5C6-mappedCitation-34781202 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34781202 |