| http://purl.uniprot.org/citations/34785595 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34785595 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) have recently emerged as important regulators of ion channel expression. We show here that select miR-106b family members repress the expression of the KCNQ2 K+ channel protein by binding to the 3'-untranslated region of KCNQ2 messenger RNA. During the first few weeks after birth, the expression of miR-106b family members rapidly decreases, whereas KCNQ2 protein level inversely increases. Overexpression of miR-106b mimics resulted in a reduction in KCNQ2 protein levels. Conversely, KCNQ2 levels were up-regulated in neurons transfected with antisense miRNA inhibitors. By constructing more specific and stable forms of miR-106b controlling systems, we further confirmed that overexpression of precursor-miR-106b-5p led to a decrease in KCNQ current density and an increase in firing frequency of hippocampal neurons, while tough decoy miR-106b-5p dramatically increased current density and decreased neuronal excitability. These results unmask a regulatory mechanism of KCNQ2 channel expression in early postnatal development and hint at a role for miR-106b up-regulation in the pathophysiology of epilepsy."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.2110200118"xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Kim K."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Kim H.J."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Kim B.I."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Kim K.W."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Baek M."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/author | "Suh B.C."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/pages | "e2110200118"xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/title | "Posttranscriptional modulation of KCNQ2 gene expression by the miR-106b microRNA family."xsd:string |
| http://purl.uniprot.org/citations/34785595 | http://purl.uniprot.org/core/volume | "118"xsd:string |
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