http://purl.uniprot.org/citations/34791963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/34791963 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundNext-generation sequencing has been proven to be a reliable method for the detection of genetic causes in heterogeneous ocular disorders. In this report an NGS-based diagnostic approach was taken to uncover the genetic etiology in a patient with coloboma and microphthalmia, a highly heterogeneous disease with intrafamilial phenotypic variability.Materials and methodsNext generation sequencing using a targeted panel of 316 genes, was carried out in the proband. Prioritized variants were then identified and confirmed using Sanger sequencing. Prenatal diagnosis of the detected variant was then performed in the family.ResultsA novel de novo frameshift variant c.157_164delTTCACTCG (p.Phe53fs) in OTX2, leading to a truncated protein, was identified. Prenatal diagnosis identified the same variant in the fetus.ConclusionsThis report demonstrates the importance of genetic counseling and underscores the efficiency and effectiveness of targeted NGS as a means of detecting variants in inherited eye disorders."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.org/dc/terms/identifier | "doi:10.1080/13816810.2021.2002915"xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Amiri H."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Ghaffari S.R."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Rafati M."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Hoseini A."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Hoseininasab F."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Mohamadhashem F."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Barati Z."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Darzi Ramandi S."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Fakhri L."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Jalilian K."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Mahmoudi A.H."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/author | "Mostofinezhad N."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/name | "Ophthalmic Genet"xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/pages | "262-267"xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/title | "Identification of a novel de novo variant in OTX2 in a patient with congenital microphthalmia using targeted next-generation sequencing followed by prenatal diagnosis."xsd:string |
http://purl.uniprot.org/citations/34791963 | http://purl.uniprot.org/core/volume | "43"xsd:string |
http://purl.uniprot.org/citations/34791963 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34791963 |
http://purl.uniprot.org/citations/34791963 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34791963 |
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http://purl.uniprot.org/uniprot/#_A0A0A7NV24-mappedCitation-34791963 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34791963 |