| http://purl.uniprot.org/citations/34795444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34795444 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34795444 | http://www.w3.org/2000/01/rdf-schema#comment | "The signals driving the adaptation of type 2 dendritic cells (DC2s) to diverse peripheral environments remain mostly undefined. We show that differentiation of CD11blo migratory DC2s-a DC2 population unique to the dermis-required IL-13 signaling dependent on the transcription factors STAT6 and KLF4, whereas DC2s in lung and small intestine were STAT6-independent. Similarly, human DC2s in skin expressed an IL-4 and IL-13 gene signature that was not found in blood, spleen and lung DCs. In mice, IL-13 was secreted homeostatically by dermal innate lymphoid cells and was independent of microbiota, TSLP or IL-33. In the absence of IL-13 signaling, dermal DC2s were stable in number but remained CD11bhi and showed defective activation in response to allergens, with diminished ability to support the development of IL-4+GATA3+ helper T cells (TH), whereas antifungal IL-17+RORγt+ TH cells were increased. Therefore, homeostatic IL-13 fosters a noninflammatory skin environment that supports allergic sensitization."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-021-01067-0"xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41590-021-01067-0"xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Yang J."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Sher A."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Sher A."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Mackay C.R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Mackay C.R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "von Daake S."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "von Daake S."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Hepworth M.R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Hepworth M.R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Chandler J.S."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Chandler J.S."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Tussiwand R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Tussiwand R."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Brombacher F."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Brombacher F."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Gallego-Ortega D."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Gallego-Ortega D."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Lamiable O."xsd:string |
| http://purl.uniprot.org/citations/34795444 | http://purl.uniprot.org/core/author | "Lamiable O."xsd:string |