| http://purl.uniprot.org/citations/34798063 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34798063 | http://www.w3.org/2000/01/rdf-schema#comment | "Severe infection can dramatically alter blood production, but the mechanisms driving hematopoietic stem and progenitor cell (HSC/HSPC) loss have not been clearly defined. Using Ixodes ovatus Ehrlichia (IOE), a tick-borne pathogen that causes severe shock-like illness and bone marrow (BM) aplasia, type I and II interferons (IFNs) promoted loss of HSPCs via increased cell death and enforced quiescence. IFN-αβ were required for increased interleukin 18 (IL-18) expression during infection, correlating with ST-HSC loss. IL-18 deficiency prevented BM aplasia and increased HSC/HSPCs. IL-18R signaling was intrinsically required for ST-HSC quiescence, but not for HSPC cell death. To elucidate cell death mechanisms, MLKL- or gasdermin D-deficient mice were infected; whereas Mlkl-/- mice exhibited protected HSC/HSPCs, no such protection was observed in Gsdmd-/- mice during infection. MLKL deficiency intrinsically protected HSCs during infection and improved hematopoietic output upon recovery. These studies define MLKL and IL-18R signaling in HSC loss and suppressed hematopoietic function in shock-like infection."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.stemcr.2021.10.011"xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/author | "Fredman G."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/author | "Howard J.E."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/author | "MacNamara K.C."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/author | "Smith J.N.P."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/name | "Stem Cell Reports"xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/pages | "2887-2899"xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/title | "IL-18R-mediated HSC quiescence and MLKL-dependent cell death limit hematopoiesis during infection-induced shock."xsd:string |
| http://purl.uniprot.org/citations/34798063 | http://purl.uniprot.org/core/volume | "16"xsd:string |
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