| http://purl.uniprot.org/citations/34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34812766 | http://www.w3.org/2000/01/rdf-schema#comment | "Undifferentiated carcinoma of the gastrointestinal tract has variable rhabdoid features. Expression of switch/sucrose nonfermenting (SWI/SNF) complex subunits is reportedly lost in a portion of cases; however, the prognostic significance of this loss remains unknown. Herein, 30 undifferentiated carcinoma cases were assessed for the expression of 4 SWI/SNF complex subunits (SMARCB1, SMARCA2, SMARCA4, and ARID1A). Tumor origin sites comprised stomach (40.0%), large intestine (20.0%), small intestine (16.7%), lower esophagus and stomach fundus (13.3%), ileocecal junction (3.3%), rectum (3.3%), and pancreas (3.3%). The tumors were composed of epithelioid neoplastic cells arranged in diffuse solid or discohesive sheets, nests, cords, poor cohesive pseudoglandular, and trabecular patterns. Rhabdoid tumor cells were identified in 66.7% (20/30) of cases. In total, 29/30 (96.7%) showed complete loss of at least 1 SWI/SNF subunit: SMARCA4-/SMARCA2- (11), isolated SMARCA4-(2), SMARCA4-/SMARCA2 unknown (6), isolated SMARCA2- (7), SMARCA2-/ARID1A-(1), and isolated ARID1A-(2). Negative or decreased expression (≤10% positive) of pan-cytokeratin was observed in 58.6% (17/29) of cases. In addition, 66.7% (20/30) of patients were late-stage (III or IV), and 65.2% (15/23) of stage IIB to IV patients succumbed to the disease at a mean clinical follow-up of 12.7 months. Specifically, patients with loss of SMARCA4 expression had the worst overall survival (P=0.028) and disease-free survival (P=0.006) rates, compared with those with SMARCA4 expression. The loss or decreased expression of epithelial markers is thus common in SWI/SNF complex-deficient undifferentiated carcinoma of the gastrointestinal tract, and loss of SMARCA4 correlates with poor prognosis."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.org/dc/terms/identifier | "doi:10.1097/pas.0000000000001836"xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Huang D."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Chang B."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Zhu X."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Weng W."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Tan C."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Ni S."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/author | "Sheng W."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/name | "Am J Surg Pathol"xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/pages | "889-906"xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/title | "SWI/SNF Complex-deficient Undifferentiated Carcinoma of the Gastrointestinal Tract: Clinicopathologic Study of 30 Cases With an Emphasis on Variable Morphology, Immune Features, and the Prognostic Significance of Different SMARCA4 and SMARCA2 Subunit Deficiencies."xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/34812766 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34812766 |
| http://purl.uniprot.org/citations/34812766 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34812766 |
| http://purl.uniprot.org/uniprot/#_A7E2E1-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |
| http://purl.uniprot.org/uniprot/#_A5D6X0-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |
| http://purl.uniprot.org/uniprot/#_B3KNW7-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |
| http://purl.uniprot.org/uniprot/#_B4DK35-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |
| http://purl.uniprot.org/uniprot/#_B4DSI8-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |
| http://purl.uniprot.org/uniprot/#_B4DSC8-mappedCitation-34812766 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34812766 |