| http://purl.uniprot.org/citations/34816768 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34816768 | http://www.w3.org/2000/01/rdf-schema#comment | "Aim: Phenytoin (PHT) is a common anticonvulsant agent known for inducing severe cutaneous adverse reactions (SCARs). HLA-B*15:02 as a risk factor of PHT-induced SCARs was reported in numerous studies with inconsistent results. This meta-analysis aimed to establish pooling evidence of this association. Materials & methods: Pooled odds ratios (ORs) with 95% CIs were estimated using a random-effects model. Results: A total of 11 studies on 1389 patients, were included for the analyses. There was a significant association between HLA-B*15:02 and PHT-induced SCAR (pooled OR = 2.29, 95% CI: 1.25-4.19, p = 0.008). Furthermore, there was a significant association regarding Stevens-Johnson syndrome/toxic epidermal necrolysis (OR = 3.63, 95% CI: 2.15-6.13, p < 0.001) but no association regarding drug reaction with eosinophilia and systemic symptom. Conclusion: The results supported the recommendations of HLA-B*15:02 screening before treatment with PHT."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.org/dc/terms/identifier | "doi:10.2217/pgs-2021-0126"xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/author | "Nguyen T.K."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/author | "Phung T.H."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/author | "Cong Duong K.N."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/author | "Junio Gloria M.A."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/name | "Pharmacogenomics"xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/pages | "49-59"xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/title | "The association between HLA-B*15:02 and phenytoin-induced severe cutaneous adverse reactions: a meta-analysis."xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/34816768 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34816768 |
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