| http://purl.uniprot.org/citations/34828269 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34828269 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiosperm flowers are the most complex organs that plants generate, and in their center, the gynoecium forms, assuring sexual reproduction. Gynoecium development requires tight regulation of developmental regulators across time and tissues. How simple on and off regulation of gene expression is achieved in plants was described previously, but molecular mechanisms generating complex expression patterns remain unclear. We use the gynoecium developmental regulator CRABS CLAW (CRC) to study factors contributing to its sophisticated expression pattern. We combine in silico promoter analyses, global TF-DNA interaction screens, and mutant analyses. We find that miRNA action, DNA methylation, and chromatin remodeling do not contribute substantially to CRC regulation. However, 119 TFs, including SEP3, ETT, CAL, FUL, NGA2, and JAG bind to the CRC promoter in yeast. These TFs finetune transcript abundance as homodimers by transcriptional activation. Interestingly, temporal-spatial aspects of expression regulation may be under the control of redundantly acting genes and require higher order complex formation at TF binding sites. Our work shows that endogenous regulation of complex expression pattern requires orchestrated transcription factor action on several conserved promotor sites covering almost 4 kb in length. Our results highlight the utility of comprehensive regulators screens directly linking transcriptional regulators with their targets."xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.org/dc/terms/identifier | "doi:10.3390/genes12111663"xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/author | "Becker A."xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/author | "Gross T."xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/name | "Genes (Basel)"xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/pages | "1663"xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/title | "Transcription Factor Action Orchestrates the Complex Expression Pattern of CRABS CLAW in Arabidopsis."xsd:string |
| http://purl.uniprot.org/citations/34828269 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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