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http://purl.uniprot.org/citations/34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34835089http://www.w3.org/2000/01/rdf-schema#comment"Single-cell RNA sequencing (scRNA-seq) offers the possibility to monitor both host and pathogens transcriptomes at the cellular level. Here, public scRNA-seq datasets from Drosophila melanogaster midgut cells were used to compare the differences in replication strategy and cellular responses between two fly picorna-like viruses, Thika virus (TV) and D. melanogaster Nora virus (DMelNV). TV exhibited lower levels of viral RNA accumulation but infected a higher number of cells compared to DMelNV. In both cases, viral RNA accumulation varied according to cell subtype. The cellular heat shock response to TV and DMelNV infection was cell-subtype- and virus-specific. Disruption of bottleneck genes at later stages of infection in the systemic response, as well as of translation-related genes in the cellular response to DMelNV in two cell subtypes, may affect the virus replication."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.org/dc/terms/identifier"doi:10.3390/v13112284"xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/author"Nagata T."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/author"Elena S.F."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/author"Melo F.L."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/author"Silva J.M.F."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/name"Viruses"xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/pages"2284"xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/title"Heterogeneity in the Response of Different Subtypes of Drosophila melanogaster Midgut Cells to Viral Infections."xsd:string
http://purl.uniprot.org/citations/34835089http://purl.uniprot.org/core/volume"13"xsd:string
http://purl.uniprot.org/citations/34835089http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34835089
http://purl.uniprot.org/citations/34835089http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34835089
http://purl.uniprot.org/uniprot/#_P11147-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_C7LA75-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_A8JNS4-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_M9MSL3-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_F3YDH0-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_M9PCD9-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_O96818-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_P22813-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_M9NE68-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_Q867H6-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089
http://purl.uniprot.org/uniprot/#_Q86BZ1-mappedCitation-34835089http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34835089