| http://purl.uniprot.org/citations/34836941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34836941 | http://www.w3.org/2000/01/rdf-schema#comment | "The PKCε-regulated genome protective pathway provides transformed cells a failsafe to successfully complete mitosis. Despite the necessary role for Aurora B in this programme, it is unclear whether its requirement is sufficient or if other PKCε cell cycle targets are involved. To address this, we developed a trapping strategy using UV-photocrosslinkable amino acids encoded in the PKCε kinase domain. The validation of the mRNA binding protein SERBP1 as a PKCε substrate revealed a series of mitotic events controlled by the catalytic form of PKCε. PKCε represses protein translation, altering SERBP1 binding to the 40 S ribosomal subunit and promoting the assembly of ribonucleoprotein granules containing SERBP1, termed M-bodies. Independent of Aurora B, SERBP1 is shown to be necessary for chromosome segregation and successful cell division, correlating with M-body formation. This requirement for SERBP1 demonstrates that Aurora B acts in concert with translational regulation in the PKCε-controlled pathway exerting genome protection."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-27189-5"xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Davis K."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Jones A."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Parker P.J."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Xie X."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Mann D.J."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "McDonald N.Q."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Ule J."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Armstrong A."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Martini S."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Elze L."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Lockwood N."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/author | "Faraway R."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/pages | "6934"xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/title | "A genetically-encoded crosslinker screen identifies SERBP1 as a PKCepsilon substrate influencing translation and cell division."xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34836941 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34836941 |
| http://purl.uniprot.org/citations/34836941 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34836941 |
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| http://purl.uniprot.org/uniprot/#_Q02156-mappedCitation-34836941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34836941 |
| http://purl.uniprot.org/uniprot/#_L7RTI5-mappedCitation-34836941 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34836941 |