| http://purl.uniprot.org/citations/34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34842272 | http://www.w3.org/2000/01/rdf-schema#comment | "Development involves tightly paced, reproducible sequences of events, yet it must adjust to conditions external to it, such as resource availability and organismal damage. A major mediator of damage-induced immune responses in vertebrates and insects is JAK/STAT signaling. At the same time, JAK/STAT activation by the Drosophila Upd cytokines is pleiotropically involved in normal development of multiple organs. Whether inflammatory and developmental JAK/STAT roles intersect is unknown. Here, we show that JAK/STAT is active during development of the prothoracic gland (PG), which controls metamorphosis onset through ecdysone production. Reducing JAK/STAT signaling decreased PG size and advanced metamorphosis. Conversely, JAK/STAT hyperactivation by overexpression of pathway components or SUMOylation loss caused PG hypertrophy and metamorphosis delay. Tissue damage and tumors, known to secrete Upd cytokines, also activated JAK/STAT in the PG and delayed metamorphosis, at least in part by inducing expression of the JAK/STAT target Apontic. JAK/STAT damage signaling, therefore, regulates metamorphosis onset by co-opting its developmental role in the PG. Our findings in Drosophila provide insights on how systemic effects of damage and cancer can interfere with hormonally controlled development and developmental transitions."xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.org/dc/terms/identifier | "doi:10.1242/dmm.049160"xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/author | "Cao X."xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/author | "Rojas M."xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/author | "Pastor-Pareja J.C."xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/name | "Dis Model Mech"xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/pages | "dmm049160"xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/title | "Intrinsic and damage-induced JAK/STAT signaling regulate developmental timing by the Drosophila prothoracic gland."xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://purl.uniprot.org/core/volume | "15"xsd:string |
| http://purl.uniprot.org/citations/34842272 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34842272 |
| http://purl.uniprot.org/citations/34842272 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHN3-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS6-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS7-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHY2-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KI37-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LEH9-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6M4-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6T9-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K7W1-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KH10-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6I1-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |
| http://purl.uniprot.org/uniprot/#_A0A0B4JCQ7-mappedCitation-34842272 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34842272 |