| http://purl.uniprot.org/citations/34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34848685 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulatory T cells (Treg cells) inhibit effector T cells and maintain immune system homeostasis. Treg cell maturation in peripheral sites requires inhibition of protein kinase mTORC1 and TGF-beta-1 (TGF-beta). While Treg cell maturation requires protein synthesis, mTORC1 inhibition downregulates it, leaving unanswered how Treg cells achieve essential mRNA translation for development and immune suppression activity. Using human CD4+ T cells differentiated in culture and genome-wide transcription and translation profiling, here we report that TGF-beta transcriptionally reprograms naive T cells to express Treg cell differentiation and immune suppression mRNAs, while mTORC1 inhibition impairs translation of T cell mRNAs but not those induced by TGF-beta. Rather than canonical mTORC1/eIF4E/eIF4G translation, Treg cell mRNAs utilize the eIF4G homolog DAP5 and initiation factor eIF3d in a non-canonical translation mechanism that requires cap-dependent binding by eIF3d directed by Treg cell mRNA 5' noncoding regions. Silencing DAP5 in isolated human naive CD4+ T cells impairs their differentiation into Treg cells. Treg cell differentiation is mediated by mTORC1 downregulation and TGF-beta transcriptional reprogramming that establishes a DAP5/eIF3d-selective mechanism of mRNA translation."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-27087-w"xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Schneider R.J."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Volta V."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Katsara O."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "de la Parra C."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Ernlund A."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Perez-Baos S."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/author | "Dornbaum S."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/pages | "6979"xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/title | "A DAP5/eIF3d alternate mRNA translation mechanism promotes differentiation and immune suppression by human regulatory T cells."xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34848685 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34848685 |
| http://purl.uniprot.org/citations/34848685 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34848685 |
| http://purl.uniprot.org/uniprot/#_B4DZF2-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_B4E1K8-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_D3DQV9-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_Q2TU89-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_Q3LIE0-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_O15371-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_P78344-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |
| http://purl.uniprot.org/uniprot/#_Q59G42-mappedCitation-34848685 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34848685 |