| http://purl.uniprot.org/citations/34855088 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34855088 | http://www.w3.org/2000/01/rdf-schema#comment | "We studied the effects of pregnancy-specific β1-glycoprotein (PSG) on the replicative potential of naïve T cells (CD45RA+) and immune memory T cells (CD45R0+) in vitro by evaluating the expression of the hTERT gene in combination with the proliferative activity of cells. Human PSG was obtained by the author's patented method of immunopurification using a biospecific sorbent with subsequent removal of immunoglobulin contamination on a HiTrap Protein G HP column. We used monocultures of CD45RA+ and CD45R0+ lymphocytes isolated from peripheral blood mononuclear cells of reproductive-age women. It was found that PSG in physiological concentrations inhibited the expression of the hTERT gene mRNA in naïve T cells and immune memory T cells and simultaneously reduced the number of proliferating T cells estimated by the differential gating method. At the same time, PSG reduced CD71 expression only on naïve T cells without affecting this molecule on immune memory T cells. Thus, PSG decreased the replication potential and suppressed the proliferation of T cells and immune memory T cells, which in the context of pregnancy can contribute to the formation of immune tolerance to the semi-allogeneic embryo."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10517-021-05357-3"xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Khaziakhmatova O.G."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Litvinova L.S."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Yurova K.A."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Bochkova M.S."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Khramtsov P.V."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Raev M.B."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Timganova V.P."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/author | "Zamorina S.A."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/name | "Bull Exp Biol Med"xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/pages | "169-174"xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/title | "Effect of Pregnancy Specific beta1-Glycoprotein on the Replicative Potential of Naive T Cells and Immune Memory T Cells."xsd:string |
| http://purl.uniprot.org/citations/34855088 | http://purl.uniprot.org/core/volume | "172"xsd:string |
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