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http://purl.uniprot.org/citations/34855866http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34855866http://www.w3.org/2000/01/rdf-schema#comment"

Aims

To compare the cervicovaginal levels of human beta defensin (hBD)-1, 2 and 3 of women according to the status of Nugent-defined bacterial vaginosis (BV).

Methods

A total of 634 women of reproductive age were included in the study. Participants were equally distributed in two groups: according to the classification of vaginal smears according to Nugent criteria in normal (scores 0 to 3) and BV (scores ≥7). Cervicovaginal fluid samples were used for measurements of hBDs1, 2 and 3 levels by enzyme-linked immunosorbent assay (ELISA). Levels of each hBD were compared between the two study groups using Mann-Whitney test, with p-value <0.05 considered as significant. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for sociodemographic variables and hBD1-3 levels associated with BV a multivariable analysis. Correlation between Nugent score and measured levels of hBDs1-3 were calculated using Spearman's test.

Results

Cervicovaginal fluids from women with BV showed lower levels of hBD-1 [median 2,400.00 pg/mL (0-27,800.00); p<0.0001], hBD-2 [5,600.00 pg/mL (0-45,800.00); p<0.0001] and hBD-3 [1,600.00 pg/mL (0-81,700.00); p = 0.012] when compared to optimal microbiota [hBD-1: [median 3,400.00 pg/mL (0-35,600.00), hBD-2: 12,300.00 pg/mL (0-95,300.00) and hBD-3: 3,000.00 pg/mL (0-64,300.00), respectively]. Multivariable analysis showed that lower levels of hBD-1 (OR: 2.05; 95% CI: 1.46-2.87), hBD-2 (OR: 1.85; 95% CI: 1.32-2.60) and hBD-3 (OR: 1.90; 95% CI: 1.37-2.64) were independently associated BV. Significant negative correlations were observed between Nugent scores and cervicovaginal levels of hBD-1 (Spearman's rho = -0.2118; p = 0.0001) and hBD-2 (*Spearman's rho = -0.2117; p = 0.0001).

Conclusions

Bacterial vaginosis is associated with lower cervicovaginal levels of hBDs1-3 in reproductive-aged women."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.org/dc/terms/identifier"doi:10.1371/journal.pone.0260753"xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Silva M.C."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Novak J."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Marconi C."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Polettini J."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Bento G.F.C."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Bolpetti A.N."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Ferreira J.S.B."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Morales J.A.P."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Noda-Nicolau N.M."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Pinto G.V.S."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Silva M.G.D."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/author"Tronco J.A."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/name"PLoS One"xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/pages"e0260753"xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/title"Cervicovaginal levels of human beta defensins during bacterial vaginosis."xsd:string
http://purl.uniprot.org/citations/34855866http://purl.uniprot.org/core/volume"16"xsd:string
http://purl.uniprot.org/citations/34855866http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34855866
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http://purl.uniprot.org/uniprot/#_A0A894JZ42-mappedCitation-34855866http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34855866
http://purl.uniprot.org/uniprot/#_C7S8D6-mappedCitation-34855866http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34855866
http://purl.uniprot.org/uniprot/#_O15263-mappedCitation-34855866http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34855866
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