| http://purl.uniprot.org/citations/34857772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34857772 | http://www.w3.org/2000/01/rdf-schema#comment | "Despite the increasing global burden of neurological disorders, there is a lack of effective diagnostic and therapeutic biomarkers. Proteins are often dysregulated in disease and have a strong genetic component. Here, we carry out a protein quantitative trait locus analysis of 184 neurologically-relevant proteins, using whole genome sequencing data from two isolated population-based cohorts (Nā=ā2893). In doing so, we elucidate the genetic landscape of the circulating proteome and its connection to neurological disorders. We detect 214 independently-associated variants for 107 proteins, the majority of which (76%) are cis-acting, including 114 variants that have not been previously identified. Using two-sample Mendelian randomisation, we identify causal associations between serum CD33 and Alzheimer's disease, GPNMB and Parkinson's disease, and MSR1 and schizophrenia, describing their clinical potential and highlighting drug repurposing opportunities."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41467-021-27387-1"xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Navarro P."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Shen X."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Wilson J.F."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Dedoussis G."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Gilly A."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Zeggini E."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Wheeler E."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Wareham N.J."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Langenberg C."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Tsafantakis E."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Barysenka A."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Pietzner M."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Repetto L."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Malarstig A."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Karaleftheri M."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/author | "Png G."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/name | "Nat Commun"xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/pages | "7042"xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/title | "Mapping the serum proteome to neurological diseases using whole genome sequencing."xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34857772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34857772 |