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http://purl.uniprot.org/citations/34859867http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34859867http://www.w3.org/2000/01/rdf-schema#comment"

Objective

Genetic mechanisms have been involved in the pathogenesis of obesity and weight loss due to bariatric surgery. The aim of our work was to evaluate the effects of rs2419621 genetic variant of ACSL5 gene on weight and metabolic changes after a robotic sleeve gastrectomy.

Patients and methods

48 patients were enrolled. Comorbidities, biochemical and anthropometric parameters evaluation were registered before and after 3, 6 and 12 months follow up. Genotype of rs2419621 ACSL5 gene was evaluated.

Results

We classified the subjects with a dominant model, in two groups: those carriers T allele (TT+CT, 37.5%) and non-carriers T allele (CC, 62.5%).  We reported a statistically significant reduction of body weight, waist circumference, percentage of excess of weight loss (EWL%), blood pressure, glucose, insulin, LDL-cholesterol and triglycerides after surgery. After 12 months, delta of (EWL%; 70.1% vs. 64,2%; p=0.04), weight (40.7+4.1 kg vs. 32.5+4.8 kg; p=0.03), waist circumference (29.1+3.1 cm vs. 22.2+2.8 kg; p=0.02) and triglycerides (51.2+9.1 mg/dl vs. 32.1+8.1; p=0.02) were higher in T allele carriers than non-T allele carriers. All comorbidities improved, but the percentage of patients with hypertriglyceridemia diminished early in the 3-month follow-up in the T-allele carriers, and at 12 months, no patient with the T allele had hypertriglyceridemia.

Conclusions

Our data showed that the genetic variant (rs2419621) of ACSL5 gene are associated with better improvement of adiposity and triglyceride levels in subjects with T allele, after a robotic sleeve gastrectomy."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.org/dc/terms/identifier"doi:10.26355/eurrev_202111_27254"xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/author"Pacheco D."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/author"Primo D."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/author"Izaola O."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/author"de Luis D."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/name"Eur Rev Med Pharmacol Sci"xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/pages"7037-7043"xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/title"The gene variant rs2419621 of ACYL-CoA synthetase long-chain 5 gene is associated with weight loss and metabolic changes in response to a robotic sleeve gastrectomy in morbid obese subjects."xsd:string
http://purl.uniprot.org/citations/34859867http://purl.uniprot.org/core/volume"25"xsd:string
http://purl.uniprot.org/citations/34859867http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34859867
http://purl.uniprot.org/citations/34859867http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34859867
http://purl.uniprot.org/uniprot/#_B4DX30-mappedCitation-34859867http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34859867
http://purl.uniprot.org/uniprot/#_Q9ULC5-mappedCitation-34859867http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34859867
http://purl.uniprot.org/uniprot/Q9ULC5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34859867
http://purl.uniprot.org/uniprot/B4DX30http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34859867