| http://purl.uniprot.org/citations/34871241 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34871241 | http://www.w3.org/2000/01/rdf-schema#comment | "AbstractFurther improvement of the diagnostic and prognostic performance of biomarkers for the critically ill is needed. Procalcitonin (PCT), placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 raise interest for sepsis diagnosis and prognosis.Serum samples from 2 cohorts of 172 patients (derivation cohort) and of 164 patients (validation cohort) comprising only patients with microbiologically confirmed gram-negative infections were analyzed. PlGF, s-Flt-1 and procalcitonin (PCT) were measured in serum within 24 hours from sepsis onset and repeated on days 3 and 7.PCT and s-Flt-1 baseline levels were higher in sepsis and septic shock compared to non-sepsis; this was not the case for PlGF. s-Flt-1 at concentrations greater than 60 pg/ml diagnosed sepsis with sensitivity 72.3% and specificity 54.9% whereas at concentrations greater than 70 pg/ml predicted unfavorable outcome with specificity 73.0% and sensitivity 63.7%. At least 80% decrease of PCT and/or PCT less than 0.5 ng/ml on day 7 was protective from sepsis-associated death.Both s-Flt-1 and PCT should be measured in the critically ill since they provide additive information for sepsis diagnosis and prognosis.ClinicalTrials.gov numbers NCT01223690 and NCT00297674."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.org/dc/terms/identifier | "doi:10.1097/md.0000000000027662"xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Giamarellos-Bourboulis E.J."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Tsangaris I."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Lada M."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Koutelidakis I.M."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Kyriazopoulou E."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/author | "Vittoros V."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/name | "Medicine (Baltimore)"xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/pages | "e27662"xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/title | "Soluble fms-like tyrosine kinase 1, placental growth factor and procalcitonin as biomarkers of gram-negative sepsis: Analysis through a derivation and a validation cohort."xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://purl.uniprot.org/core/volume | "100"xsd:string |
| http://purl.uniprot.org/citations/34871241 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34871241 |
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