| http://purl.uniprot.org/citations/34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34871323 | http://www.w3.org/2000/01/rdf-schema#comment | "Protective immunity to parasitic infections has been difficult to elicit by vaccines. Among parasites that evade vaccine-induced immunity is Toxoplasma gondii, which causes lethal secondary infections in chronically infected mice. Here we report that unlike susceptible C57BL/6J mice, A/J mice were highly resistant to secondary infection. To identify correlates of immunity, we utilized forward genetics to identify Nfkbid, a nuclear regulator of NF-κB that is required for B cell activation and B-1 cell development. Nfkbid-null mice ("bumble") did not generate parasite-specific IgM and lacked robust parasite-specific IgG, which correlated with defects in B-2 cell maturation and class-switch recombination. Though high-affinity antibodies were B-2 derived, transfer of B-1 cells partially rescued the immunity defects observed in bumble mice and were required for 100% vaccine efficacy in bone marrow chimeric mice. Immunity in resistant mice correlated with robust isotype class-switching in both B cell lineages, which can be fine-tuned by Nfkbid gene expression. We propose a model whereby humoral immunity to T. gondii is regulated by Nfkbid and requires B-1 and B-2 cells for full protection."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.ppat.1010081"xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Luo Z."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Baumgarth N."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Alvarez J.A."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Souza S.P."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Wilson J.N."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Sanchez-Arcila J.C."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Jensen K.D.C."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Splitt S.D."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/author | "Wizzard S."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/name | "PLoS Pathog"xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/pages | "e1010081"xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/title | "Genetic mapping reveals Nfkbid as a central regulator of humoral immunity to Toxoplasma gondii."xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/34871323 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34871323 |
| http://purl.uniprot.org/citations/34871323 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34871323 |
| http://purl.uniprot.org/uniprot/#_A0A075B5P6-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |
| http://purl.uniprot.org/uniprot/#_A0A075B6A0-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |
| http://purl.uniprot.org/uniprot/#_A0A217FL61-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |
| http://purl.uniprot.org/uniprot/#_Q2TB02-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |
| http://purl.uniprot.org/uniprot/#_P01872-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |
| http://purl.uniprot.org/uniprot/#_Q924Q3-mappedCitation-34871323 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34871323 |