| http://purl.uniprot.org/citations/34882885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34882885 | http://www.w3.org/2000/01/rdf-schema#comment | "Sinoatrial node (SAN) pacemaker cells originate from T-box transcription factor 18 (Tbx18)-expressing progenitor cells. The present study aimed to investigate whether overexpression of human transcription factor Tbx18 could reprogram human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) into SAN-like pacemaker cells (SANLPCs) in vitro. In the study, hiPSCs were first differentiated into hiPSC-CMs through regulating the Wnt/β-catenin pathway, then purified hiPSC-CMs were transfected by Tbx18 adenovirus (Tbx18-CMs group) or green fluorescent protein (GFP) adenovirus (GFP-CMs group). The beating frequency of the Tbx18-CMs group was significantly higher than that of the hiPSC-CMs group and GFP-CMs group. Compared with the other two groups, the expression levels of hyperpolarization-activated cyclic nucleotide-gated potassium channel isoform 4, connexin-45 in the Tbx18-CMs group were markedly upregulated, while the expressions of transcription factor NKX2.5, CX43 were significantly downregulated. Whole-cell patch-clamp results illustrated that action potential and "funny" current (If ) similar to SAN pacemaker cells could be recorded in the Tbx18-CMs group. In conclusion, this present study demonstrated that overexpression of Tbx18 promoted the conversion of hiPSC-CMs into SANLPCs."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.org/dc/terms/identifier | "doi:10.1002/cbin.11738"xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Tang Y."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Zhang W."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Zhao H."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/author | "Quan D."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/name | "Cell Biol Int"xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/pages | "403-414"xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/title | "Tbx18 promoted the conversion of human-induced pluripotent stem cell-derived cardiomyocytes into sinoatrial node-like pacemaker cells."xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://purl.uniprot.org/core/volume | "46"xsd:string |
| http://purl.uniprot.org/citations/34882885 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34882885 |
| http://purl.uniprot.org/citations/34882885 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34882885 |
| http://purl.uniprot.org/uniprot/#_O95935-mappedCitation-34882885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34882885 |
| http://purl.uniprot.org/uniprot/#_Q8IW86-mappedCitation-34882885 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34882885 |
| http://purl.uniprot.org/uniprot/O95935 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34882885 |
| http://purl.uniprot.org/uniprot/Q8IW86 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34882885 |