| http://purl.uniprot.org/citations/34887565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34887565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34887565 | http://www.w3.org/2000/01/rdf-schema#comment | "RNA polymerase I (Pol I) specifically synthesizes ribosomal RNA. Pol I upregulation is linked to cancer, while mutations in the Pol I machinery lead to developmental disorders. Here we report the cryo-EM structure of elongating human Pol I at 2.7 Å resolution. In the exit tunnel, we observe a double-stranded RNA helix that may support Pol I processivity. Our structure confirms that human Pol I consists of 13 subunits with only one subunit forming the Pol I stalk. Additionally, the structure of human Pol I in complex with the initiation factor RRN3 at 3.1 Å resolution reveals stalk flipping upon RRN3 binding. We also observe an inactivated state of human Pol I bound to an open DNA scaffold at 3.3 Å resolution. Lastly, the high-resolution structure of human Pol I allows mapping of disease-related mutations that can aid understanding of disease etiology."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-021-00693-4"xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.org/dc/terms/identifier | "doi:10.1038/s41594-021-00693-4"xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Baudin F."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Baudin F."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Girbig M."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Girbig M."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Grotsch H."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Grotsch H."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Lafita A."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Lafita A."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Misiaszek A.D."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Misiaszek A.D."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Murciano B."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/author | "Murciano B."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/pages | "997-1008"xsd:string |
| http://purl.uniprot.org/citations/34887565 | http://purl.uniprot.org/core/pages | "997-1008"xsd:string |