| http://purl.uniprot.org/citations/34898351 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34898351 | http://www.w3.org/2000/01/rdf-schema#comment | "For humans, gastric cancer (GC) is a common malignancy. Multiple circular RNAs (circRNAs) have been confirmed to be important cancer-promoting or tumor-suppressive factors. The present study discusses the roles and mechanisms of circ_0000423 in GC development. In this study, circ_0000423 expression in GC patient tissue samples and cell lines was detected via quantitative real-time polymerase chain reaction. Disheveled-Axin domain containing 1 (DIXDC1) expression in GC cells was examined via Western blot. Besides, cell counting kit-8 was utilized for detecting GC cell viability. GC cell migration and invasion were examined through Transwell assays. Bioinformatics and dual-luciferase reporter gene assays were employed to verify the regulatory relationships between microRNA-582-3p (miR-582-3p) and circ_0000423 or DIXDC1. In the present study, we demonstrated that circ_0000423 was highly expressed in GC. Circ_0000423 knockdown suppressed GC cell viability, migration and invasion. Moreover, miR-582-3p was confirmed as a direct target of circ_0000423, and an upstream regulator of DIXDC1. MiR-582-3p inhibition or DIXDC1 overexpression could reverse the above-mentioned effects of knocking down circ_0000423 on GC cells. In conclusion, circ_0000423 facilitates GC progression by modulating the miR-582-3p/DIXDC1 axis."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.org/dc/terms/identifier | "doi:10.1080/21655979.2021.1997696"xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Liu J."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Yang X."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Yang P."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Huang C.Q."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Wang Y.P."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/author | "Hao D.D."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/name | "Bioengineered"xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/pages | "12755-12766"xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/title | "Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis."xsd:string |
| http://purl.uniprot.org/citations/34898351 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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