| http://purl.uniprot.org/citations/34899399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34899399 | http://www.w3.org/2000/01/rdf-schema#comment | "Brown and beige adipocytes are specialized to dissipate energy as heat. Sgk2, encoding a serine/threonine kinase, has been identified as a brown and beige adipocyte-specific gene in rodents and humans; however, its function in brown/beige adipocytes remains unraveled. Here, we examined the regulation and role of Sgk2 in brown/beige adipose tissue thermogenesis. We found that transcriptional coactivators PGC-1α and NT-PGC-1α activated by the β3 adrenergic receptor-cAMP-PKA pathway are recruited to the Sgk2 promoter, triggering Sgk2 transcription in response to cold. SGK2 elevation was closely associated with increased serine/threonine phosphorylation of proteins carrying the consensus RxRxxS/T phosphorylation site. However, despite cold-dependent activation of SGK2, mice lacking Sgk2 exhibited normal cold tolerance at 4°C. In addition, Sgk2+/+ and Sgk2-/- mice induced comparable increases in energy expenditure during pharmacological activation of brown and beige adipose tissue with a β3AR agonist. In vitro loss- and gain-of-function studies further demonstrated that Sgk2 ablation or activation does not alter thermogenic gene expression and mitochondrial respiration in brown adipocytes. Collectively, our results reveal a new signaling component SGK2, although dispensable for cold-induced thermogenesis that adds an additional layer of complexity to the β3AR signaling network in brown/beige adipose tissue."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.org/dc/terms/identifier | "doi:10.3389/fphys.2021.780312"xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Cheng H."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Lee J."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Park M."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Park C.H."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Moon J."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/author | "Chang J.S."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/name | "Front Physiol"xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/pages | "780312"xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/title | "Protein Kinase SGK2 Is Induced by the betapisub>3pi/sub> Adrenergic Receptor-cAMP-PKA-PGC-1alpha/NT-PGC-1alpha Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis."xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://purl.uniprot.org/core/volume | "12"xsd:string |
| http://purl.uniprot.org/citations/34899399 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34899399 |
| http://purl.uniprot.org/citations/34899399 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34899399 |
| http://purl.uniprot.org/uniprot/#_Q9QZS5-mappedCitation-34899399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34899399 |
| http://purl.uniprot.org/uniprot/#_Q3UW73-mappedCitation-34899399 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34899399 |
| http://purl.uniprot.org/uniprot/Q9QZS5 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34899399 |
| http://purl.uniprot.org/uniprot/Q3UW73 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34899399 |