| http://purl.uniprot.org/citations/34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34902430 | http://www.w3.org/2000/01/rdf-schema#comment | "Arrestins regulate a wide range of signaling events, most notably when bound to active G protein-coupled receptors (GPCRs). Among the known effectors recruited by GPCR-bound arrestins are Src family kinases, which regulate cellular growth and proliferation. Here, we focus on arrestin-3 interactions with Fgr kinase, a member of the Src family. Previous reports demonstrated that Fgr exhibits high constitutive activity, but can be further activated by both arrestin-dependent and arrestin-independent pathways. We report that arrestin-3 modulates Fgr activity with a hallmark bell-shaped concentration-dependence, consistent with a role as a signaling scaffold. We further demonstrate using NMR spectroscopy that a polyproline motif within arrestin-3 interacts directly with the SH3 domain of Fgr. To provide a framework for this interaction, we determined the crystal structure of the Fgr SH3 domain at 1.9 Å resolution and developed a model for the GPCR-arrestin-3-Fgr complex that is supported by mutagenesis. This model suggests that Fgr interacts with arrestin-3 at multiple sites and is consistent with the locations of disease-associated Fgr mutations. Collectively, these studies provide a structural framework for arrestin-dependent activation of Fgr."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.jmb.2021.167400"xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Agarwal R."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Iverson T.M."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Sanders C.R."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Smith J.C."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Gurevich V.V."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Vishnivetskiy S.A."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Castro M.A."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Perez I."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/author | "Berndt S."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/name | "J Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/pages | "167400"xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/title | "A Model for the Signal Initiation Complex Between Arrestin-3 and the Src Family Kinase Fgr."xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://purl.uniprot.org/core/volume | "434"xsd:string |
| http://purl.uniprot.org/citations/34902430 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34902430 |
| http://purl.uniprot.org/citations/34902430 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34902430 |
| http://purl.uniprot.org/uniprot/#_B7Z6W7-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |
| http://purl.uniprot.org/uniprot/#_B7Z9D2-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |
| http://purl.uniprot.org/uniprot/#_P09769-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |
| http://purl.uniprot.org/uniprot/#_P78453-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |
| http://purl.uniprot.org/uniprot/#_P78483-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |
| http://purl.uniprot.org/uniprot/#_Q7KZ45-mappedCitation-34902430 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34902430 |