| http://purl.uniprot.org/citations/3491986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3491986 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3491986 | http://www.w3.org/2000/01/rdf-schema#comment | "Steroid 21-hydroxylase [21-OHase; steroid 21-monooxygenase; steroid, hydrogen-donor:oxygen oxidoreductase (21-hydroxylating); EC 1.14.99.10] is a cytochrome P-450 enzyme required for the adrenal synthesis of mineralocorticoids and glucocorticoids. The gene encoding this protein is present in two copies (21-OHase A and B) in the S region of the murine major histocompatibility complex. Previous studies utilizing gene-specific oligonucleotide probes and gene transfer showed that only the 21-OHase A gene is expressed in the BALB/c mouse. Here, we present the complete primary structures of both BALB/c 21-OHase encoding genes. Comparison of the nucleotide sequences defines a deletion of 215 nucleotides spanning the second exon of the 21-OHase B gene; other nucleotide changes in the 21-OHase B gene introduce frame shifts and premature termination codons. Southern blot analysis of C57BL/6 and DBA/2J mice indicates that a similar deletion is present in these strains; however the C3H/HeJ strain is a structural variant. A hybrid gene composed of the 21-OHase B promoter placed 5' of the 21-OHase A structural sequences was efficiently transcribed following transfection into Y1 adrenocortical tumor cells. These findings demonstrate that the 21-OHase B gene promoter is functional and suggest that mutations within the 21-OHase B structural gene are responsible for its lack of expression."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.83.24.9601"xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.83.24.9601"xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Seidman J.G."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Seidman J.G."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Parker K.L."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Parker K.L."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "White P.C."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "White P.C."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Chaplin D.D."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Chaplin D.D."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Galbraith L.J."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/author | "Galbraith L.J."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/date | "1986"xsd:gYear |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/pages | "9601-9605"xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/pages | "9601-9605"xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/title | "Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/title | "Nucleotide sequence analysis of murine 21-hydroxylase genes: mutations affecting gene expression."xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/volume | "83"xsd:string |
| http://purl.uniprot.org/citations/3491986 | http://purl.uniprot.org/core/volume | "83"xsd:string |