| http://purl.uniprot.org/citations/34932950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34932950 | http://www.w3.org/2000/01/rdf-schema#comment | "Myoblast fusion is essential for muscle development and regeneration. Yet, it remains poorly understood how mononucleated myoblasts fuse with preexisting fibers. We demonstrate that ERK1/2 inhibition (ERKi) induces robust differentiation and fusion of primary mouse myoblasts through a linear pathway involving RXR, ryanodine receptors, and calcium-dependent activation of CaMKII in nascent myotubes. CaMKII activation results in myotube growth via fusion with mononucleated myoblasts at a fusogenic synapse. Mechanistically, CaMKII interacts with and regulates MYMK and Rac1, and CaMKIIδ/γ knockout mice exhibit smaller regenerated myofibers following injury. In addition, the expression of a dominant negative CaMKII inhibits the formation of large multinucleated myotubes. Finally, we demonstrate the evolutionary conservation of the pathway in chicken myoblasts. We conclude that ERK1/2 represses a signaling cascade leading to CaMKII-mediated fusion of myoblasts to myotubes, providing an attractive target for the cultivated meat industry and regenerative medicine."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.devcel.2021.11.022"xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Avinoam O."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Segev N."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Schejter E.D."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Zaritsky A."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Amzallag E."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Tzahor E."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Millay D.P."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Eigler T."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Umansky K.B."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Zarfati G."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Shakked A."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/author | "Zabary Y."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/name | "Dev Cell"xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/pages | "3349-3363.e6"xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/title | "ERK1/2 inhibition promotes robust myotube growth via CaMKII activation resulting in myoblast-to-myotube fusion."xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/34932950 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34932950 |
| http://purl.uniprot.org/citations/34932950 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34932950 |
| http://purl.uniprot.org/uniprot/#_D3Z7K9-mappedCitation-34932950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34932950 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGS4-mappedCitation-34932950 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34932950 |