| http://purl.uniprot.org/citations/3493439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3493439 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/3493439 | http://www.w3.org/2000/01/rdf-schema#comment | "T-cell receptors (TCRs) recognize foreign antigens in the context of major histocompatibility complex (MHC)-encoded cell surface proteins. These receptors are heterogeneous, dimeric glycoproteins composed of disulphide linked alpha- and beta-chains. We analysed the diversity of TCRs in a collection of H-2Kb-restricted, 2,4,6-trinitrophenyl (TNP)-specific (H-2Kb/TNP) cytotoxic T-cell (Tc) clones from C57BL/6 mice. Investigation of the beta-chain messenger RNAs revealed that nearly half of these independent clones expressed an identical beta-chain gene. We show here that almost all the Tc clones expressing the predominant beta-chain gene also express an identical alpha-chain gene. These results show that a strong selective pressure acted on the Tc population, resulting in a skewing of the TCR repertoire for H-2Kb/TNP and in the dominant expression of one TCR with this specificity. Possible explanations for this skewing include antigen-driven clonal expansion and network interactions."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.org/dc/terms/identifier | "doi:10.1038/326307a0"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.org/dc/terms/identifier | "doi:10.1038/326307a0"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Becker A."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Becker A."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Epplen J.T."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Epplen J.T."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Hochgeschwender U."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Hochgeschwender U."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Simon H.G."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Simon H.G."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Bartels F."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Bartels F."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Weltzien H.U."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/author | "Weltzien H.U."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/date | "1987"xsd:gYear |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/pages | "307-309"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/pages | "307-309"xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/title | "Dominance of one T-cell receptor in the H-2Kb/TNP response."xsd:string |
| http://purl.uniprot.org/citations/3493439 | http://purl.uniprot.org/core/title | "Dominance of one T-cell receptor in the H-2Kb/TNP response."xsd:string |