DESCRIBE <http://purl.uniprot.org/citations/34936547>

Subject	Predicate	Object
http://purl.uniprot.org/citations/34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34936547	http://www.w3.org/2000/01/rdf-schema#comment	" Objectives The role of epigenetic mechanisms in the pathogenesis and course of RA as well as response to treatment is increasingly being emphasised. The aim of our study was to determine the ADAMTSL2 and LRPAP1 gene methylation levels in RA patients' serum divided according to disease activity and in comparison with the results with the control group. Methods Quantitative real-time methylation-specific PCR was used to analyse the methylation status of the investigated genes. Results We observed a significant difference in the methylation levels of both the ADAMTSL2 and the LRPAP1 genes in patients with high RA activity compared to patients in remission. Conclusions ADAMTSL2 methylation status was inversely correlated with DAS28. High disease activity was associated with lower methylation levels than in remission as well as in the control group. Different results were obtained for the methylation levels of the LRPAP1 gene. High disease activity and the control group were characterised by a higher level of LRPAP1 gene methylation compared to patients in remission. We have proven that methylation may play an important role in the course and severity of RA. The level of ADAMTSL2 and LRPAP1 gene methylation might impact the development of disease and reflect the activity of RA."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.org/dc/terms/identifier	"doi:10.55563/clinexprheumatol/ogk9sd"xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/author	"Ciesla M."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/author	"Majdan M."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/author	"Kolarz B."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/author	"Podgorski R."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/author	"Podgorska D."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/date	"2022"xsd:gYear
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/name	"Clin Exp Rheumatol"xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/pages	"2052-2059"xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/title	"The relationship of ADAMTSL2 and LRPAP1 gene methylation level with rheumatoid arthritis activity."xsd:string
http://purl.uniprot.org/citations/34936547	http://purl.uniprot.org/core/volume	"40"xsd:string
http://purl.uniprot.org/citations/34936547	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/34936547
http://purl.uniprot.org/citations/34936547	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/34936547
http://purl.uniprot.org/uniprot/#_A8K8F6-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_B4DE73-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_B2R6S9-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_B3KXC5-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_P30533-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_Q86TH1-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/#_Q96I42-mappedCitation-34936547	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/P30533	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/Q86TH1	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34936547
http://purl.uniprot.org/uniprot/B2R6S9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/34936547