| http://purl.uniprot.org/citations/34951404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34951404 | http://www.w3.org/2000/01/rdf-schema#comment | "In meiosis, DNA double-strand break (DSB) formation by Spo11 initiates recombination and enables chromosome segregation. Numerous factors are required for Spo11 activity, and couple the DSB machinery to the development of a meiosis-specific 'axis-tethered loop' chromosome organisation. Through in vitro reconstitution and budding yeast genetics, we here provide architectural insight into the DSB machinery by focussing on a foundational DSB factor, Mer2. We characterise the interaction of Mer2 with the histone reader Spp1, and show that Mer2 directly associates with nucleosomes, likely highlighting a contribution of Mer2 to tethering DSB factors to chromatin. We reveal the biochemical basis of Mer2 association with Hop1, a HORMA domain-containing chromosomal axis factor. Finally, we identify a conserved region within Mer2 crucial for DSB activity, and show that this region of Mer2 interacts with the DSB factor Mre11. In combination with previous work, we establish Mer2 as a keystone of the DSB machinery by bridging key protein complexes involved in the initiation of meiotic recombination."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.72330"xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Muller F."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Janning P."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Raina V.B."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Vader G."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Weir J.R."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Altmannova V."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Liedtke D."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Funk S.K."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Nivsarkar V."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Reichle H."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/author | "Rousova D."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/pages | "e72330"xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/title | "Novel mechanistic insights into the role of Mer2 as the keystone of meiotic DNA break formation."xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://purl.uniprot.org/core/volume | "10"xsd:string |
| http://purl.uniprot.org/citations/34951404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34951404 |
| http://purl.uniprot.org/citations/34951404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34951404 |
| http://purl.uniprot.org/uniprot/#_P21651-mappedCitation-34951404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34951404 |
| http://purl.uniprot.org/uniprot/P21651 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/34951404 |