| http://purl.uniprot.org/citations/34969359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34969359 | http://www.w3.org/2000/01/rdf-schema#comment | "Long noncoding RNAs (lncRNAs) have been identified as prognostic biomarkers and functional regulators in human tumors. In our study, we aim to investigate the roles of lncRNA SND1-IT1 (SND1-IT1) in retinoblastoma (RB). We observed that SND1-IT1 was highly expressed in both RB specimens and cells, and associated with poorer prognosis of RB patients. Functional investigation revealed that downregulation of SND1-IT1 suppressed RB cell proliferation, migration and invasion in vitro and restrained RB tumorigenesis in vivo. MiR-132-3p was predicted to interact with SND1-IT1. RT-qPCR and dual-luciferase reporter assays verified the regulation of miR-132-3p by SND1-IT1 in RB cells. In addition, SND1-IT1 enhanced the expression of SMAD2 by sponging miR-132-3p. Rescue experiments revealed that knockdown of miR-132-3p reversed the inhibiting effects of miR-132-3p knockdown on RB cells. Overall, SND1-IT1 can promote the progression of RB cells through miR-132-3p/SMAD2 axis, suggesting that l SND1-IT1 might be a novel biomarker and potential target for RB."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.org/dc/terms/identifier | "doi:10.1080/21655979.2021.1909962"xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/author | "Zhou X.J."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/author | "Yuan H."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/author | "Liu H.J."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/author | "Yin D.F."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/name | "Bioengineered"xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/pages | "1189-1201"xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/title | "Long non-coding RNA SND1-IT1 accelerates cell proliferation, invasion and migration via regulating miR-132-3p/SMAD2 axis in retinoblastoma."xsd:string |
| http://purl.uniprot.org/citations/34969359 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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