| http://purl.uniprot.org/citations/34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/34971382 | http://www.w3.org/2000/01/rdf-schema#comment | "Population genetics seeks to illuminate the forces shaping genetic variation, often based on a single snapshot of genomic variation. However, utilizing multiple sampling times to study changes in allele frequencies can help clarify the relative roles of neutral and non-neutral forces on short time scales. This study compares whole-genome sequence variation of recently collected natural population samples of Drosophila melanogaster against a collection made approximately 35 years prior from the same locality-encompassing roughly 500 generations of evolution. The allele frequency changes between these time points would suggest a relatively small local effective population size on the order of 10,000, significantly smaller than the global effective population size of the species. Some loci display stronger allele frequency changes than would be expected anywhere in the genome under neutrality-most notably the tandem paralogs Cyp6a17 and Cyp6a23, which are impacted by structural variation associated with resistance to pyrethroid insecticides. We find a genome-wide excess of outliers for high genetic differentiation between old and new samples, but a larger number of adaptation targets may have affected SNP-level differentiation versus window differentiation. We also find evidence for strengthening latitudinal allele frequency clines: northern-associated alleles have increased in frequency by an average of nearly 2.5% at SNPs previously identified as clinal outliers, but no such pattern is observed at random SNPs. This project underscores the scientific potential of using multiple sampling time points to investigate how evolution operates in natural populations, by quantifying how genetic variation has changed over ecologically relevant timescales."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.org/dc/terms/identifier | "doi:10.1093/molbev/msab368"xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/author | "Pool J.E."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/author | "Lack J.B."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/author | "Bastide H."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/author | "Lange J.D."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/name | "Mol Biol Evol"xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/pages | "msab368"xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/title | "A Population Genomic Assessment of Three Decades of Evolution in a Natural Drosophila Population."xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/34971382 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/34971382 |
| http://purl.uniprot.org/citations/34971382 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/34971382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFS5-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFU0-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4KEY9-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DHG9-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4LF54-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4K6R9-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
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| http://purl.uniprot.org/uniprot/#_A0A0B4K884-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHE2-mappedCitation-34971382 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/34971382 |