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http://purl.uniprot.org/citations/34992344http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/34992344http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To investigate the correlation of the Val109Asp polymorphism of the omentin-1 gene with the risk and severity of knee osteoarthritis (KOA) in a Chinese Han population.

Methods

This study enrolled 383 patients with primary KOA and 460 healthy controls. The genotypes were determined by the detection of single nucleotide polymorphism. To explore the interaction between omentin-1 gene polymorphism and obesity and age, the body mass index (BMI) of 25 kg/m2 and the age of 55 years old were preset as the cut-off value of stratified analysis. Furthermore, enzyme-linked immunosorbent assay was used to determine the levels of omentin-1, interleukin (IL)-1β, IL-6 in peripheral blood and synovial fluid and the contents of IL-1β, IL-6, metalloproteinase (MMP)-13 and collagen (COL)-II in the supernatant of knee joint cartilage tissue.

Results

The Val109Asp polymorphism of the omentin-1 gene showed no obvious correlation with KOA. Compared with Asp/Asp genotype carriers with BMI <25 kg/m2 and age <55 years old, Val109 allele carriers with BMI≥25 kg/m2 and age ≥55 years old had obviously increased risk of KOA (adjusted OR = 1.416, p = 0.042; adjusted OR = 1.735, p = 0.038, respectively). In the KOA group, only the omentin-1 levels were significantly lower in the plasma and synovial fluid of Ala/Ala genotype carriers than in those of Asp/Asp genotype carriers. Meanwhile, the proportion of patients with moderate-severe K-L Classification, the levels of IL-1β, IL-6 in synovial fluid and the expression levels of IL-1β, IL-6 and MMP-13 in cartilage tissue significantly increased (p < 0.05). By contrast, the expression level of COL-II in cartilage tissue significantly decreased (p < 0.05).

Conclusions

The Val109Asp polymorphism of the omentin-1 gene may not be the primary pathogenic factor of KOA in Chinese. The Val/Val genotype can be regarded as a potential biomarker for the risk of KOA progression."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.org/dc/terms/identifier"doi:10.2147/dddt.s340410"xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Chen M."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Chen R."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Hu H."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Zhang Y."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Xu H."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/author"Shuai Z."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/date"2021"xsd:gYear
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/name"Drug Des Devel Ther"xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/pages"5075-5086"xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/title"Val109Asp Polymorphism of the Omentin-1 Gene and Incidence of Knee Osteoarthritis in a Chinese Han Population: A Correlation Analysis."xsd:string
http://purl.uniprot.org/citations/34992344http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/34992344http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/34992344
http://purl.uniprot.org/citations/34992344http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/34992344
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http://purl.uniprot.org/uniprot/#_Q8WWA0-mappedCitation-34992344http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/34992344
http://purl.uniprot.org/uniprot/Q8WWA0http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34992344
http://purl.uniprot.org/uniprot/Q5IWS5http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/34992344