| http://purl.uniprot.org/citations/35003057 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35003057 | http://www.w3.org/2000/01/rdf-schema#comment | "JAK/STAT signaling regulates central biological functions such as development, cell differentiation and immune responses. In Drosophila, misregulated JAK/STAT signaling in blood cells (hemocytes) induces their aberrant activation. Using mass spectrometry to analyze proteins associated with a negative regulator of the JAK/STAT pathway, and by performing a genome-wide RNAi screen, we identified several components of the proteasome complex as negative regulators of JAK/STAT signaling in Drosophila. A selected proteasome component, Prosα6, was studied further. In S2 cells, Prosα6 silencing decreased the amount of the known negative regulator of the pathway, ET, leading to enhanced expression of a JAK/STAT pathway reporter gene. Silencing of Prosα6 in vivo resulted in activation of the JAK/STAT pathway, leading to the formation of lamellocytes, a specific hemocyte type indicative of hemocyte activation. This hemocyte phenotype could be partially rescued by simultaneous knockdown of either the Drosophila STAT transcription factor, or MAPKK in the JNK-pathway. Our results suggest a role for the proteasome complex components in the JAK/STAT pathway in Drosophila blood cells both in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.729631"xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Ramet M."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Valanne S."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Vesala L."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Jarvela-Stolting M."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Ciantar J."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/author | "Maasdorp M.K."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/pages | "729631"xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/title | "Proteasome alpha6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation in pii>Drosophila melanogasterpi/i>."xsd:string |
| http://purl.uniprot.org/citations/35003057 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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