| http://purl.uniprot.org/citations/35017636 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35017636 | http://www.w3.org/2000/01/rdf-schema#comment | "High-grade serous ovarian carcinoma (HGSOC) is the most aggressive gynecological malignancy, resulting in approximately 70% of ovarian cancer deaths. However, it is still unclear how genetic dysregulations and biological processes generate the malignant subtype of HGSOC. Here we show that expression levels of microtubule affinity-regulating kinase 3 (MARK3) are downregulated in HGSOC, and that its downregulation significantly correlates with poor prognosis in HGSOC patients. MARK3 overexpression suppresses cell proliferation and angiogenesis of ovarian cancer cells. The LKB1-MARK3 axis is activated by metabolic stress, which leads to the phosphorylation of CDC25B and CDC25C, followed by induction of G2/M phase arrest. RNA-seq and ATAC-seq analyses indicate that MARK3 attenuates cell cycle progression and angiogenesis partly through downregulation of AP-1 and Hippo signaling target genes. The synthetic lethal therapy using metabolic stress inducers may be a promising therapeutic choice to treat the LKB1-MARK3 axis-dysregulated HGSOCs."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.org/dc/terms/identifier | "doi:10.1038/s42003-021-02992-4"xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Asada K."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Fujii T."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Kato T."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Oda K."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Yoshida H."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Kaneko S."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Nakato R."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Komatsu M."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Hamamoto R."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Sone K."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Osuga Y."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Ikawa N."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Saloura V."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Machino H."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "von Keudell G."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Dozen A."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/author | "Shozu K."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/name | "Commun Biol"xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/pages | "39"xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/title | "The metabolic stress-activated checkpoint LKB1-MARK3 axis acts as a tumor suppressor in high-grade serous ovarian carcinoma."xsd:string |
| http://purl.uniprot.org/citations/35017636 | http://purl.uniprot.org/core/volume | "5"xsd:string |