| http://purl.uniprot.org/citations/35026645 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35026645 | http://www.w3.org/2000/01/rdf-schema#comment | "Breast cancer (BC) ranks as the highest incidence among cancer types in women all over the world. Triple-negative breast cancer (TNBC) is known as a highly aggressive subtype of BC due to high rate of recurrence and metastasis, poor prognosis and lacking of effective targeted therapies. MicroRNAs (miRNAs) are a class of short endogenous non-coding RNA that mostly functioning to silence the target mRNAs. In this study, we found miR-181c-5p (miR-181c) was down-expressed in TNBC tissues and cell lines, whereas MAP4K4 was highly-expressed. Up-regulation of miR-181c inhibited TNBC cells proliferation and migration, promoted TNBC cells apoptosis and regulated the cell cycle by arresting cells in the G0/G1 cell phase, while depletion of miR-181c showed opposite effect. Importantly, miR-181c suppressed MAP4K4 expression at both mRNA and protein levels by directly targeting MAP4K4, thereby inhibiting the tumor-promoting effect of MAP4K4. This study is the first to demonstrate the miR-181c/MAP4K4 signaling in suppressing TNBC, providing a novel therapeutic target for TNBC."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.prp.2022.153763"xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/author | "Fang L."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/author | "Li S."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/author | "Xie D."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/name | "Pathol Res Pract"xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/pages | "153763"xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/title | "MiR-181c suppresses triple-negative breast cancer tumorigenesis by targeting MAP4K4."xsd:string |
| http://purl.uniprot.org/citations/35026645 | http://purl.uniprot.org/core/volume | "230"xsd:string |
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