| http://purl.uniprot.org/citations/35037428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35037428 | http://www.w3.org/2000/01/rdf-schema#comment | "The Plk1-interacting checkpoint helicase (PICH) protein localizes to ultrafine anaphase DNA bridges in mitosis along with a complex of DNA repair proteins. Previous studies show PICH deficiency-induced embryonic lethality in mice. However, the function of PICH that is required to suppress embryonic lethality in PICH-deficient mammals remains to be determined. Previous clinical studies suggest a link between PICH deficiency and the onset of acquired aplastic anemia. Here, using Pich knock-out (KO) mouse models, the authors provide evidence for a mechanistic link between PICH deficiency and defective hematopoiesis. Fetal livers from Pich-KO embryos exhibit a significantly elevated number of hematopoietic stem cells (HSCs); however, these HSCs display a higher level of apoptosis and a much-reduced ability to reconstitute a functional hematopoietic system when transplanted into lethally irradiated recipients. Moreover, these HSCs show an elevated cytoplasmic dsDNA expression and an activation of the cGAS-STING pathway, resulting in excessive production of type I interferons (IFN). Importantly, deletion of Ifnar1 or cGAS reverses the defective hematopoiesis. The authors conclude that loss of PICH results in defective hematopoiesis via cGAS-STING-mediated type I IFN production."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.org/dc/terms/identifier | "doi:10.1002/advs.202103837"xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Feng H."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Li F."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Li W."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Shen H."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Zhang C."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Zhang L."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Ying S."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Xing M."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Hickson I.D."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Geng X."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/author | "Ji F."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/name | "Adv Sci (Weinh)"xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/pages | "e2103837"xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/title | "PICH Supports Embryonic Hematopoiesis by Suppressing a cGAS-STING-Mediated Interferon Response."xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/35037428 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35037428 |
| http://purl.uniprot.org/citations/35037428 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35037428 |
| http://purl.uniprot.org/uniprot/#_A0A125R9I3-mappedCitation-35037428 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037428 |