| http://purl.uniprot.org/citations/35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35037620 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed that in Drosophila starvation-independent quality control autophagy is regulated by acinus (acn) and the Cdk5-dependent phosphorylation of its serine437 (Nandi et al., 2017). Here, we identify the phosphatase that counterbalances this activity and provides for the dynamic nature of acinus-serine437 (acn-S437) phosphorylation. A genetic screen identified six phosphatases that genetically interacted with an acn gain-of-function model. Among these, loss of function of only one, the PPM-type phosphatase Nil (CG6036), enhanced pS437-acn levels. Cdk5-dependent phosphorylation of acn-S437 in nil1 animals elevates neuronal autophagy and reduces the accumulation of polyQ proteins in a Drosophila Huntington's disease model. Consistent with previous findings that Cd2+ inhibits PPM-type phosphatases, Cd2+ exposure elevated acn-S437 phosphorylation which was necessary for increased neuronal autophagy and protection against Cd2+-induced cytotoxicity. Together, our data establish the acn-S437 phosphoswitch as critical integrator of multiple stress signals regulating neuronal autophagy."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.72169"xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/author | "Kramer H."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/author | "Tracy C."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/author | "Zaidi Z."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/author | "Nandi N."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/pages | "e72169"xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/title | "A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress."xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35037620 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35037620 |
| http://purl.uniprot.org/citations/35037620 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35037620 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KHS9-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_A0A0B4LFR7-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_A0A4D6K293-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_A8QI94-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_H5V895-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_M9PGI3-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_P48461-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_M9NE01-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_P11612-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_P48462-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |
| http://purl.uniprot.org/uniprot/#_P48609-mappedCitation-35037620 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35037620 |