| http://purl.uniprot.org/citations/35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35042581 | http://www.w3.org/2000/01/rdf-schema#comment | "In the thymus, the thymic epithelium provides a microenvironment essential for the development of functionally competent and self-tolerant T cells. Previous findings showed that modulation of Wnt/β-catenin signaling in mouse thymic epithelial cells (TECs) disrupts embryonic thymus organogenesis. However, the role of β-catenin in TECs for postnatal T-cell development remains to be elucidated. Here, we analyzed gain-of-function (GOF) and loss-of-function (LOF) of β-catenin highly specific in mouse TECs. We found that GOF of β-catenin in TECs results in severe thymic dysplasia and T-cell deficiency beginning from the embryonic period. By contrast, LOF of β-catenin in TECs reduces the number of cortical TECs and thymocytes modestly and only postnatally. These results indicate that fine-tuning of β-catenin expression within a permissive range is required for TECs to generate an optimal microenvironment to support postnatal T-cell development."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.org/dc/terms/identifier | "doi:10.7554/elife.69088"xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Abe H."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Matsushita Y."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Fujimori S."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Katagiri T."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Taketo M.M."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Ohigashi I."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/author | "Takahama Y."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/name | "Elife"xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/pages | "e69088"xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/title | "Fine-tuning of beta-catenin in mouse thymic epithelial cells is required for postnatal T-cell development."xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/35042581 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35042581 |
| http://purl.uniprot.org/citations/35042581 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35042581 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_D3Z7S6-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_A1E2H6-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |
| http://purl.uniprot.org/uniprot/#_F7CRC6-mappedCitation-35042581 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35042581 |