| http://purl.uniprot.org/citations/35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35043944 | http://www.w3.org/2000/01/rdf-schema#comment | "Establishment of a healthy ovarian reserve is contingent upon numerous regulatory pathways during embryogenesis. Previously, mice lacking TBP-associated factor 4b (Taf4b) were shown to exhibit a diminished ovarian reserve. However, potential oocyte-intrinsic functions of TAF4b have not been examined. Here, we use a combination of gene expression profiling and chromatin mapping to characterize TAF4b-dependent gene regulatory networks in mouse oocytes. We find that Taf4b-deficient oocytes display inappropriate expression of meiotic, chromatin modification/organization, and X-linked genes. Furthermore, dysregulated genes in Taf4b-deficient oocytes exhibit an unexpected amount of overlap with dysregulated genes in oocytes from XO female mice, a mouse model of Turner Syndrome. Using Cleavage Under Targets and Release Using Nuclease (CUT&RUN), we observed TAF4b enrichment at genes involved in chromatin remodeling and DNA repair, some of which are differentially expressed in Taf4b-deficient oocytes. Interestingly, TAF4b target genes were enriched for Sp/Klf family and NFY target motifs rather than TATA-box motifs, suggesting an alternative mode of promoter interaction. Together, our data connect several gene regulatory nodes that contribute to the precise development of the mammalian ovarian reserve."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.200074"xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Wu T."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Kaya H."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Fazzio T.G."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Freiman R.N."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Turner J.M.A."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Seymour K.A."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Abt K.M."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Gura M.A."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/author | "Relovska S."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/pages | "dev200074"xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/title | "TAF4b transcription networks regulating early oocyte differentiation."xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://purl.uniprot.org/core/volume | "149"xsd:string |
| http://purl.uniprot.org/citations/35043944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35043944 |
| http://purl.uniprot.org/citations/35043944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/35043944 |
| http://purl.uniprot.org/uniprot/#_E9Q0S7-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |
| http://purl.uniprot.org/uniprot/#_E9Q113-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |
| http://purl.uniprot.org/uniprot/#_A0A3B2W725-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |
| http://purl.uniprot.org/uniprot/#_A0A3Q4EGS4-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |
| http://purl.uniprot.org/uniprot/#_A0A979HLR9-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |
| http://purl.uniprot.org/uniprot/#_A0A1D9BZF0-mappedCitation-35043944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35043944 |