| http://purl.uniprot.org/citations/35051265 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35051265 | http://www.w3.org/2000/01/rdf-schema#comment | "The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatelet formation releases into the bloodstream beads-on-a-string preplatelets, which undergo fission into mature platelets. For the first time, we show that preplatelet maturation is a third, tightly regulated, critical process akin to cytokinesis that regulates platelet count. We show that deficiency in cytokine receptor-like factor 3 (CRLF3) in mice leads to an isolated and sustained 25% to 48% reduction in the platelet count without any effect on other blood cell lineages. We show that Crlf3-/-preplatelets have increased microtubule stability, possibly because of increased microtubule glutamylation via the interaction of CRLF3 with key members of the Hippo pathway. Using a mouse model of JAK2 V617F essential thrombocythemia, we show that a lack of CRLF3 leads to long-term lineage-specific normalization of the platelet count. We thereby postulate that targeting CRLF3 has therapeutic potential for treatment of thrombocythemia."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood.2021013113"xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Adams D.J."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Mueller A."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Yan Y."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Read R.J."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Moreau T."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Nieswandt B."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Penkett C.J."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Bennett C."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Couzens A.L."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Akbari P."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Baig A."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Erber W.N."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Stritt S."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Lawrence M."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Ghevaert C."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Guerrero J.A."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Evans A.L."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Bender M."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Mayer L."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Mookerjee S."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Hoffman G.J."xsd:string |
| http://purl.uniprot.org/citations/35051265 | http://purl.uniprot.org/core/author | "Saeb-Parsy K."xsd:string |