| http://purl.uniprot.org/citations/35055160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35055160 | http://www.w3.org/2000/01/rdf-schema#comment | "Background: Triple Negative Breast Cancers (TNBC) are the most aggressive breast cancers and lead to poor prognoses. This is due to a high resistance to therapies, mainly because of the presence of Cancer Stem Cells (CSCs). Plasticity, a feature of CSCs, is acquired through the Epithelial to Mesenchymal Transition (EMT), a process that has been recently shown to be regulated by a key molecule, CD146. Of interest, CD146 is over-expressed in TNBC. Methods: The MDA-MB-231 TNBC cell line was used as a model to study the role of CD146 and its secreted soluble form (sCD146) in the development and dissemination of TNBC using in vitro and in vivo studies. Results: High expression of CD146 in a majority of MDA-MB-231 cells leads to an increased secretion of sCD146 that up-regulates the expression of EMT and CSC markers on the cells. These effects can be blocked with a specific anti-sCD146 antibody, M2J-1 mAb. M2J-1 mAb was able to reduce tumour development and dissemination in a model of cells xenografted in nude mice and an experimental model of metastasis, respectively, in part through its effects on CSC. Conclusion: We propose that M2J-1 mAb could be used as an additional therapeutic approach to fight TNBC."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.org/dc/terms/identifier | "doi:10.3390/ijms23020974"xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Robert S."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Sharma A."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Bachelier R."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Bardin N."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Blot-Chabaud M."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Leroyer A.S."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Foucault-Bertaud A."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Traboulsi W."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Somasundaram I."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Joshkon A."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/author | "Ladjimi A."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/name | "Int J Mol Sci"xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/pages | "974"xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/title | "Soluble CD146 as a Potential Target for Preventing Triple Negative Breast Cancer MDA-MB-231 Cell Growth and Dissemination."xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/35055160 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35055160 |
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| http://purl.uniprot.org/uniprot/#_P43121-mappedCitation-35055160 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/35055160 |