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| http://purl.uniprot.org/citations/35059953 | http://www.w3.org/2000/01/rdf-schema#comment | "Cytosolic estrogen sulfotransferase (SULT1E1) mainly catalyzes the sulfoconjugation and deactivation of estrogens that are known to exert potent anti-atherogenic effects. However, it remains unknown about the connection between SULT1E1 and atherosclerosis. Recently, we reported that SULT1E1 is highly expressed in the aorta with plaques of high fat-fed ApoE knockout (KO) mice (mouse model of atherosclerosis), and interacts with oxidized low-density lipoprotein (Ox-LDL) known as a major component of atherosclerotic lesions. In this study, immunohistochemical staining for SULT1E1 in the aorta of high fat-fed ApoE KO mice showed that SULT1E1 is detected in vascular endothelial cells overlying atherosclerotic plaques. Results from Western blotting showed that Ox-LDL induces the protein expression of both SULT1E1 and peroxisome proliferator-activated receptor (PPAR) γ in human umbilical vein endothelial cells (HUVECs), and then that a PPARγ antagonist GW9662, but not a PPARα antagonist GW6471, inhibited the protein expression of SULT1E1 induced by Ox-LDL. Moreover, GW9662 significantly increased the proliferation of HUVECs induced by Ox-LDL. Our results suggest that SULT1E1 and PPARγ, both of which are increased by Ox-LDL, may interact with each other, and then may reduce cooperatively Ox-LDL-induced proliferation of vascular endothelial cells overlying atherosclerotic plaques, leading to against atherosclerosis."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.org/dc/terms/identifier | "doi:10.1007/s10930-022-10042-z"xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/author | "Sato A."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/author | "Yamazaki M."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/author | "Watanabe H."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/author | "Ebina K."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/author | "Sakurai E."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/name | "Protein J"xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/pages | "179-188"xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/title | "Estrogen Sulfotransferase is Highly Expressed in Vascular Endothelial Cells Overlying Atherosclerotic Plaques."xsd:string |
| http://purl.uniprot.org/citations/35059953 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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