| http://purl.uniprot.org/citations/35079912 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35079912 | http://www.w3.org/2000/01/rdf-schema#comment | "Iron is an essential trace metal ion required for all living organisms, and is taken up by iron transporters. Here, we identified and characterized three-candidate high-affinity (Fio1, Frp1 and Frp2) and two-candidate low-affinity iron transporters (Fet4 and Pdt1) from the fission yeast Schizosaccharomyces pombe. Protein sequence analyses revealed that Fio1 is a multicopper oxidase that contains three cupredoxin domains with eleven candidate iron-binding ligands, whereas Frp1 harbors a ferric reductase domain with three-candidate heme-binding ligands. Protein sequence analyses also revealed that Fet4 and Pdt1 are integral membrane proteins with 10 and 11 transmembrane regions, respectively. Deletion of fio1 and, to a lesser extent, frp1 impaired growth under iron-depleted conditions, whereas deletion of frp1 and, to a lesser extent, frp2 inhibited growth under iron-replete conditions. Deletion of fet4 and pdt1 did not affect the growth of cells under iron-depleted and iron-replete conditions. Deletion of fio1 or frp1 also increased the sensitivity of cells to other transition metals. The copper sensitivity of Δfio1 cells could be rescued by iron, suggesting that the addition of iron might decrease the uptake of potentially toxic copper in Δfio1 cells. The copper sensitivity of Δfio1 cells could also be rescued by deletion of frp1, suggesting that Fio1 and Frp1 may function together in iron and copper uptakes in S. pombe. Our results revealed that iron and copper uptake systems may be partially overlapped in S. pombe."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.org/dc/terms/identifier | "doi:10.1007/s00203-021-02683-y"xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/author | "Ahmad F."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/author | "Huang Y."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/author | "Luo Y."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/author | "Zhang Y."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/author | "Yin H."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/name | "Arch Microbiol"xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/pages | "152"xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/title | "Identification and analysis of iron transporters from the fission yeast Schizosaccharomyces pombe."xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://purl.uniprot.org/core/volume | "204"xsd:string |
| http://purl.uniprot.org/citations/35079912 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35079912 |
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| http://purl.uniprot.org/uniprot/Q01663 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/35079912 |
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