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| http://purl.uniprot.org/citations/35080244 | http://www.w3.org/2000/01/rdf-schema#comment | "Nuclear export of mRNAs is a critical regulatory step in eukaryotic gene expression. The mRNA transcript undergoes extensive processing, and is loaded with a set of RNA-binding proteins (RBPs) to form export-competent messenger ribonucleoprotein particles (mRNPs) in the nucleus. During the transit of mRNPs through the nuclear pore complex (NPC), the DEAD-box ATPase - DDX19 (herein referring to DDX19A and DDX19B) - remodels mRNPs at the cytoplasmic side of the NPC, by removing a subset of RNA-binding proteins to terminate mRNP export. This requires the RNA-dependent ATPase activity of DDX19 and its dynamic interactions with Gle1 and Nup214. However, the regulatory mechanisms underlying these interactions are unclear. We find that DDX19 gets covalently attached with a small ubiquitin-like modifier (SUMO) at lysine 26, which enhances its interaction with Gle1. Furthermore, a SUMOylation-defective mutant of human DDX19B, K26R, failed to provide a complete rescue of the mRNA export defect caused by DDX19 depletion. Collectively, our results suggest that SUMOylation fine-tunes the function of DDX19 in mRNA export by regulating its interaction with Gle1. This study identifies SUMOylation of DDX19 as a modulatory mechanism during the mRNA export process. This article has an associated First Person interview with the first author of the paper."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.259449"xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/author | "Banerjee P."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/author | "Joseph J."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/author | "Markande S."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/author | "Kalarikkal M."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/pages | "jcs259449"xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/title | "SUMOylation modulates the function of DDX19 in mRNA export."xsd:string |
| http://purl.uniprot.org/citations/35080244 | http://purl.uniprot.org/core/volume | "135"xsd:string |
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