| http://purl.uniprot.org/citations/35082159 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35082159 | http://www.w3.org/2000/01/rdf-schema#comment | "TPL-2 kinase plays an important role in innate immunity, activating ERK1/2 MAPKs in myeloid cells following TLR stimulation. We investigated how TPL-2 controls transcription in TLR4-stimulated mouse macrophages. TPL-2 activation of ERK1/2 regulated expression of genes encoding transcription factors, cytokines, chemokines, and signaling regulators. Bioinformatics analysis of gene clusters most rapidly induced by TPL-2 suggested that their transcription was mediated by the ternary complex factor (TCF) and FOS transcription factor families. Consistently, TPL-2 induced ERK1/2 phosphorylation of the ELK1 TCF and the expression of TCF target genes. Furthermore, transcriptomic analysis of TCF-deficient macrophages demonstrated that TCFs mediate approximately half of the transcriptional output of TPL-2 signaling, partially via induced expression of secondary transcription factors. TPL-2 signaling and TCFs were required for maximal TLR4-induced FOS expression. Comparative analysis of the transcriptome of TLR4-stimulated Fos -/- macrophages indicated that TPL-2 regulated a significant fraction of genes by controlling FOS expression levels. A key function of this ERK1/2-TCF-FOS pathway was to mediate TPL-2 suppression of type I IFN signaling, which is essential for host resistance against intracellular bacterial infection."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.2100213"xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Wagner E.F."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Ley S.C."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Chakravarty P."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Bakiri L."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Papoutsopoulou S."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Blair L."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Smale S."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/author | "Pattison M.J."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/date | "2022"xsd:gYear |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/pages | "941-954"xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/title | "TPL-2 Inhibits IFN-beta Expression via an ERK1/2-TCF-FOS Axis in TLR4-Stimulated Macrophages."xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://purl.uniprot.org/core/volume | "208"xsd:string |
| http://purl.uniprot.org/citations/35082159 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/35082159 |
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