| http://purl.uniprot.org/citations/35082784 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/35082784 | http://www.w3.org/2000/01/rdf-schema#comment | "Ankylosing spondylitis (AS) belongs to a group of diseases, called spondyloarthropathies (SpA), that are strongly associated with the genetic marker HLA-B27. AS is characterized by inflammation of joints and primarily affects the spine. Over 160 subtypes of HLA-B27 are known, owing to high polymorphism. Some are strongly associated with disease (e.g., B*2704), whereas others are not (e.g., B*2709). Misfolding of HLA-B27 molecules [as dimers, or as high-molecular-weight (HMW) oligomers] is one of several hypotheses proposed to explain the link between HLA-B27 and AS. Our group has previously established the existence of HMW species of HLA-B27 in AS patients. Still, very little is known about the mechanisms underlying differences in pathogenic outcomes of different HLA-B27 subtypes. We conducted a proteomics-based evaluation of the differential disease association of HLA B*2704 and B*2709, using stable transfectants of genes encoding the two proteins. A clear difference was observed in protein clearance mechanisms: whereas unfolded protein response (UPR), autophagy, and aggresomes were involved in the degradation of B*2704, the endosome-lysosome machinery was primarily involved in B*2709 degradation. These differences offer insights into the differential disease association of B*2704 and B*2709."xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.org/dc/terms/identifier | "doi:10.3389/fimmu.2021.795053"xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/author | "Thakur A.K."xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/author | "Luthra-Guptasarma M."xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/date | "2021"xsd:gYear |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/name | "Front Immunol"xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/pages | "795053"xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/title | "Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27."xsd:string |
| http://purl.uniprot.org/citations/35082784 | http://purl.uniprot.org/core/volume | "12"xsd:string |
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